An integrated metabolomic and proteomic approach for the identification of covalent inhibitors of the main protease (Mpro) of SARS-COV-2 from crude natural extractsArticle Published on 2023-01-152022-11-15 Journal: Talanta [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Analysis applied approach baicalein binding carried catalytic characteristic Chinese complementary complex Compound Covalent binder Cys145 database drug target electrophilic Final functional HIS163 HIS164 His41 independent inhibitor inhibitors Ion knowledge M pro M(pro) mass mass spectrometry maturation metabolomic metabolomics Michael molecular dynamics MPro nucleophilic peptide platform polyprotein protease protein-ligand Proteins proteomic proteomics residue SARS-CoV-2 SARS-CoV-2. Scutellaria baicalensis tested the SARS-CoV-2 [DOI] 10.1016/j.talanta.2022.123824 PMC 바로가기
Understanding the dynamic relation between wastewater SARS-CoV-2 signal and clinical metrics throughout the pandemicArticle Published on 2022-12-202022-11-16 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha variant clinical testing Community complementary COVID-19 COVID-19 disease COVID-19 incidence deaths Delta VOC disease disease incidence Effectiveness expected Hospital admissions ICU admissions immunization incidence Infection Laboratory positive cases Metrics moderate omicron pandemic Population positive SARS-CoV-2 shown Spread Surveillance understanding vaccination vaccination rate Vaccine virulence VoC waned wastewater weakened widespread wildtype WWS. [DOI] 10.1016/j.scitotenv.2022.158458 PMC 바로가기
Expediting the chromatographic analysis of COVID-19 antibody therapeutics with ultra-short columns, retention modeling and automated method developmentArticle Published on 2022-11-302022-11-15 Journal: Journal of pharmaceutical and biomedical analysis [Category] SARS, 진단, [키워드] Analysis automated Automation Casirivimab collected complementary COVID-19 COVID-19 antibody COVID-19 pandemic drug candidate Effect Emergency use authorization EUA experimental work feasible help hospitalized patient Imdevimab infected with SARS-CoV-2 mAb mAbs monoclonal antibody passive immunity performed Protein required retention Retention modeling SEC submission turnaround times Ultra-short column. Vaccines [DOI] 10.1016/j.jpba.2022.115039 PMC 바로가기
Temporal dynamics of SARS-CoV-2 genome and detection of variants of concern in wastewater influent from two metropolitan areas in ArkansasArticle Published on 2022-11-252022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Affect approach Arkansas association Asymptomatic changes in Community complementary contribute coronavirus COVID-19 COVID-19 case COVID-19 testing death detect diagnostic Factors fecal genetic diversity Genetic variant genomic change highlight identity infected individual investigated nucleocapsid ORF1ab polymerase chain polyprotein public health quantified Quantitative recorded RNA sequencing RT-qPCR RT-qPCR assay SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 mutations SARS-CoV-2 RNA SARS-CoV-2 variant sensitivity silent Support Surface glycoprotein Surveillance TaqMan assay target Temporal the disease transmission of SARS-CoV-2 variants variants of concern viral gene viral titer virus virus genome was used wastewater Wastewater. [DOI] 10.1016/j.scitotenv.2022.157546 PMC 바로가기
An efficient approach for SARS-CoV-2 monoclonal antibody production via modified mRNA-LNP immunizationArticle Published on 2022-11-052022-11-15 Journal: International journal of pharmaceutics [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] addition Antigen antigens applied approach approaches binding affinity circumvent complementary COVID-19 COVID-19 pandemic Delta Diseases evaluated functional fusion strategy generate immunization introduced lack Lipid Lipid nanoparticle (LNP) LNP mAb mAbs Membrane proteins methodology mice Modified mRNA monoclonal antibodies monoclonal antibody neutralize Neutralizing Neutralizing activity posttranslational modification Prophylactic Protein RBD Receptor binding domain SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike SARS-CoV-2 virus SARS-CoV-2. serum serum antibody several variants therapeutic drug Treatment Vaccines variants [DOI] 10.1016/j.ijpharm.2022.122256 PMC 바로가기
Discovery of a tRNA-like base sequence in the coronavirus genome and possible mechanism of actionArticle Published on 2022-11-012022-11-16 Journal: Genes & genomics [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome base Base sequence Cloverleaf model of tRNA complementary coronavirus Evidence function genetic component Genome homology human gene intron involved mechanism of action Messenger RNA molecular Mutation mutation. produced question robust SARS-CoV SARS-CoV-2 sequence therapeutic agents viruses [DOI] 10.1007/s13258-022-01299-w PMC 바로가기
Modular nanoarray vaccine for SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Nanomedicine : nanotechnology, biology, and medici [Category] SARS, 변종, 진단, [키워드] B-cell epitope children complementary COVID-19 pandemic defined delta variant DNA effective epitope generate Gold nanoparticle IgG immune response immunized immunocompromised individuals immunogen immunogenic inactive mice mRNA neutralizing antibody PADRE peptide pregnant women probe recombinant proteins resulting SARS-CoV-2 spike glycoprotein time-consuming Vaccine Vaccine development vaccine platform Variants of concerns (VOC). virus neutralizing titer virus-like particles viruses VoC while wildtype [DOI] 10.1016/j.nano.2022.102604 PMC 바로가기
Does timing matter on tocilizumab administration? Clinical, analytical and radiological outcomes in COVID-19Article Published on 2022-11-012022-11-15 Journal: European Journal of Hospital Pharmacy [Category] SARS, 진단, [키워드] 30-Day mortality Administered administration adverse event adverse events analysed Biomarker C-reactive protein clinical Clinical improvement cohorts of patient comparable complementary Complementary therapies coronavirus disease COVID-19 Critical Critical care decrease Efficacy epidemiologically group hospitalised Hypothesis inflammatory parameters knowledge lactate dehydrogenase medication Mortality onset of symptom outcome Patient patients with COVID-19 pharmacological treatment Pneumonia Primary outcome pulmonary medicine Quotient radiological radiological improvement Radiology. randomised controlled trial reductions in SaO_{2} secondary Severe COVID-19 pneumonia statistically significant difference subgroup subgroups the timing therapy Tocilizumab tocilizumab administration two group were recorded while [DOI] 10.1136/ejhpharm-2020-002669 PMC 바로가기
Potent monoclonal antibodies neutralize Omicron sublineages and other SARS-CoV-2 variantsArticle Published on 2022-11-012022-11-15 Journal: Cell Reports [Category] SARS, 변종, 진단, [키워드] Analysis antibodies antibody Beta breadth complementary conserved CP: Immunology CP: Microbiology Efficacy Hamster model human monoclonal antibodies immune Immune escape in vivo interact monoclonal antibody mutations neutralization neutralize Neutralizing activity omicron Omicron sublineages BA.1., BA.2, BA.2.12.1, and BA.4 overcome potent Protective provide raise reduced SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein Spread the receptor-binding domain the SARS-CoV-2 therapeutic therapeutic antibodies therapeutic efficacy Vaccine variant variants variants of concern variants of concern. [DOI] 10.1016/j.celrep.2022.111528 PMC 바로가기
Evaluation of five immunoassays and one lateral flow immunochromatography for anti-SARS-CoV-2 antibodies detectionArticle Published on 2022-11-012022-11-15 Journal: Enfermedades infecciosas y microbiologia clinica ( [Category] SARS, 진단, 치료기술, [키워드] addition anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody approach caused CLIA CLIA assays Clinical practice complementary coronavirus SARS-CoV-2 COVID-19 COVID-19 patient criteria diagnostic ELISA English evaluated FIVE greater healthcare worker healthy IgG IgM IgM antibody immunoassay immunochromatographic test immunochromatography Inmunocromatografía involved lateral flow Pandemia pandemic para performed Rapid test ROC ROC curves RT-PCR SARS-CoV-2 SARS-CoV-2 coronavirus sensitivity Serología. serological serology serum sample Sin Spanish specificity Support Vaccine [DOI] 10.1016/j.eimce.2020.12.007 PMC 바로가기